Due the voluminous number of all research articles, please wait for a moment.
undoGo back

Designing magnesium-selective ligands using coordination chemistry principles

date_range 2021
person
Author Walter E.R.H.
description
Abstract Progress in the selective binding and detection of magnesium ions has been slower than other biologically important divalent metal ions like calcium and zinc. The most widely used ligands for Mg2+ are by no means optimal, as they are not selective for it. Nevertheless, Mg2+ is a major cation in all cells, with physiologically critical functions. There is a need for improved sensors for Mg2+. In this review, we consider how an appreciation of fundamental coordination chemistry principles may inform the development of new ligands for Mg2+. A number of representative examples of ligands of differing denticity are discussed in this context. Low-denticity ligands such as β-keto acids offer the best selectivities, but speciation is an issue as other polydentate ligands such as pyrophosphate may complete the coordination sphere. High-denticity ligands based on aminocarboxylates such as APTRA typically offer the highest stability constants, but they bind Ca2+ and Zn2+ more strongly than Mg2+. We highlight recent examples featuring related aminophosphinates, where the longer bonds and smaller bite angles favour selectivity towards Mg2+. Macrocyclic receptors for magnesium are not discussed explicitly. © 2020 Elsevier B.V.
article
DOI 10.1016/j.ccr.2020.213622
language
Journal Coordination Chemistry Reviews
description
Source Scopus

Submit your feeback

CARI! has performed crawling, tagging, and other data processing to produce this page. If you find an error or have feedback for this page, please fill out the form below. Thank You.
How to correct
  • Name and Email are required!
  • One of the location fields (prov, district, or sub-district) must be filled in
  • Fields other than those mentioned above are optional

Meta Tags

Source from CARI Engine
Provincies :
Cities :
Districts :
Hazards :
Sub DM Phase : Early Warning,Improve Infrastructure
Sub Aspects :

Related Research Article

Citations Articles

Source from Semantic Scholar
Rosamine derivatives of o-aminothiophenol-triacetate (S-APTRA): a new class of selective fluorescent sensors for Zn2+
Characterization of the complex-forming interactions of biogenic metal ions with a lipopeptide sialorphin derivative in an aqueous solution
Fluorescence Properties and Mg2+ Selectivity of Aryl‐Alkynyl Derivatives of the o‐Aminophenoltriacetate (APTRA) Ligand
Advances in Fluorescence/Colorimetric Dual‐Signal Sensors Enabled by Diverse Signal Activation Mechanisms
Selective Assembly between Cu2+ and β-Nicotinamide Mononucleotide (NMN).
ABEEM/MM Magnesium Force Field for Proteins and Aqueous Solutions
Enhanced Binding of Zn2+ Using a Sulfur Version of o-Aminophenol-Triacetate (APTRA): Introducing S-APTRA and Derivatives
A new macrocyclic dansyl-cyclen fluorescent probe for the identification of mildly acidic intracellular compartments
Single-step conversion of low-grade magnesite to anhydrous MgCO3 based on a biodegradable salicylic acid chelating system: Characterization; DFT calculations; mechanism
Rapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelators
Development of Phosphinate Ligand-Based Low-Affinity Ca2+ Fluorescent Probes and Application to Intracellular Ca2+ Imaging.
STRUCTURE AND THERMODYNAMIC CHARACTERISTICS OF INTERMEDIATE CATALYTIC ADDUCTS IN CUMENE OXIDATION IN THE PRESENCE OF 2-ETHYLHEXANOATES OF GROUP 2 METALS
Discovering and Targeting Dynamic Drugging Pockets of Oncogenic Proteins: The Role of Magnesium in Conformational Changes of the G12D Mutated Kirsten Rat Sarcoma-Guanosine Diphosphate Complex
Discovering and targeting dynamic drugging pockets of the oncogene KRAS-G12D
Ratiometric Fluorescence Detection of Mg2+ Based on Regulating Crown-Ether Modified Annihilators for Triplet-Triplet Annihilation Upconversion.
Magnesium-catalyzed stereoselective transformations – A survey through recent achievements
Cyclopentadienyl Complexes of the Alkaline Earths in Light of the Periodic Trends.
Enzyme-activated probes in optical imaging: a focus on atherosclerosis

References Articles

Source from Semantic Scholar
Advances in Imaging of Understudied Ions in Signaling: A Focus on Magnesium
Learning from Artemisinin: Bioinspired Design of a Reaction-Based Fluorescent Probe for the Selective Sensing of Labile Heme in Complex Biosystems.
Near-Infrared Fluorescent Probes for Imaging of Intracellular Mg2+ and Application to Multi-Color Imaging of Mg2+, ATP and Mitochondrial Membrane Potential.
Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism
On the preferences of five-membered chelate rings in coordination chemistry: insights from the Cambridge Structural Database and theoretical calculations.
Highly Selective, Red Emitting BODIPY-Based Fluorescent Indicators for Intracellular Mg2+ Imaging
APTRA-Based Luminescent Lanthanide Complexes Displaying Enhanced Selectivity for Mg2.
On the Antibacterial Activity of Azacarboxylate Ligands: Lowered Metal Ion Affinities for Bis-amide Derivatives of EDTA do not mean Reduced Activity.
Tuning Mg(II) Selectivity: Comparative Analysis of the Photophysical Properties of Four Fluorescent Probes with an Alkynyl-Naphthalene Fluorophore.
Fluorescent probes for the detection of magnesium ions (Mg2+): from design to application
Enhanced selectivity for Mg2+ with a phosphinate-based chelate: APDAP versus APTRA.
Ratiometric Imaging of Intracellular Mg2+ Dynamics Using a Red Fluorescent Turn-off Probe and a Green Fluorescent Turn-on Probe
A fluorescent activatable probe for imaging intracellular Mg2+ 
Visualization of long-term Mg2+ dynamics in apoptotic cells using a novel targetable fluorescent probe
Highly selective tridentate fluorescent probes for visualizing intracellular Mg2+ dynamics without interference from Ca2+ fluctuation.
Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet.
Recent progress in the design and applications of fluorescence probes containing crown ethers.
Inherited and acquired disorders of magnesium homeostasis
Synthesis of a highly Mg2+-selective fluorescent probe and its application to quantifying and imaging total intracellular magnesium
Tuning the Spectroscopic Properties of Ratiometric Fluorescent Metal Indicators: Experimental and Computational Studies on Mag-fura-2 and Analogues.
Bright, red emitting fluorescent sensor for intracellular imaging of Mg2+ .
Kinetically Inert Lanthanide Complexes as Reporter Groups for Binding of Potassium by 18-crown-6.
Very bright, enantiopure europium(iii) complexes allow time-gated chiral contrast imaging.
Visualizing Compartmentalized Cellular Mg2+ on Demand with Small-Molecule Fluorescent Sensors.
An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells
Genetically Encoded Fluorescent Indicators for Organellar Calcium Imaging.
Structural and spectroscopic insight into the metal binding properties of the o-aminophenol-N,N,O-triacetic acid (APTRA) chelator: implications for design of metal indicators.
Magnesium Status in Alzheimer’s Disease
Visualizing changes in mitochondrial Mg2+ during apoptosis with organelle-targeted triazole-based ratiometric fluorescent sensors
Current developments in fluorescent PET (photoinduced electron transfer) sensors and switches.
Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions.
Selective naked-eye detection of Magnesium (II) ions using a coumarin-derived fluorescent probe
Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules
Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease
Enhanced ratiometric fluorescent indicators for magnesium based on azoles of the heavier chalcogens.
Formation of Ternary Complexes with MgATP: Effects on the Detection of Mg2+ in Biological Samples by Bidentate Fluorescent Sensors
Fluorescent Sensors for Measuring Metal Ions in Living Systems
Direct imaging of ER calcium with targeted-esterase induced dye loading (TED).
A DFT analysis of the effect of chelate ring size on metal ion selectivity in complexes of polyamine ligands
The pyridyl group in ligand design for selective metal ion complexation and sensing.
Dynamics of ion-regulated photoinduced electron transfer in BODIPY-BAPTA conjugates
Chemodosimeters: An approach for detection and estimation of biologically and medically relevant metal ions, anions and thiols
Lighting the way to see inside the live cell with luminescent transition metal complexes
Cellular magnesium homeostasis.
Determining association constants from titration experiments in supramolecular chemistry.
Intracellular magnesium detection: imaging a brighter future.
Peptide-based Probes for Targeted Molecular Imaging
Fluorescent PET (photoinduced electron transfer) sensors as potent analytical tools.
Measurement of Magnesium Stability Constants of Biologically Relevant Ligands by Simultaneous Use of pH and Ion-Selective Electrodes
Coordination chemistry of macrocyclic ligands
HaloTag: a novel protein labeling technology for cell imaging and protein analysis.
Single-cell microinjection technology in cell biology.
BODIPY dyes and their derivatives: syntheses and spectroscopic properties.
Regulation of magnesium homeostasis and transport in mammalian cells.
Zinc-buffering capacity of a eukaryotic cell at physiological pZn
Preparation and use of Coppersensor-1, a synthetic fluorophore for live-cell copper imaging
Design, synthesis and photophysical studies of an emissive, europium based, sensor for zinc.
Taking advantage of luminescent lanthanide ions.
On the development of sensor molecules that display Fe(III)-amplified fluorescence.
Synthesis and spectroscopic characterisation of BODIPY based fluorescent off-on indicators with low affinity for calcium.
Design and synthesis of highly sensitive and selective fluorescein-derived magnesium fluorescent probes and application to intracellular 3D Mg2+ imaging.
Magnesium chemistry and biochemistry
Design and synthesis of Mg2+-selective fluoroionophores based on a coumarin derivative and application for Mg2+ measurement in a living cell.
Hydrogen bonding, stacking and cation binding of DNA bases
4-oxo-4H-quinolizine-3-carboxylic acids as Mg2+ selective, fluorescent indicators.
Signaling Recognition Events with Fluorescent Sensors and Switches.
A squaraine-based near IR fluorescent chemosensor for calcium
What is the concentration of calcium ions in the endoplasmic reticulum?
Magnesium deficiency: pathophysiologic and clinical overview.
Biological coordination chemistry of magnesium, sodium, and potassium ions. Protein and nucleotide binding sites
Measurement of free Zn2+ ion concentration with the fluorescent probe mag-fura-2 (furaptra).
Regulation of cell magnesium.
Chelate ring size and metal ion selection. The basis of selectivity for metal ions in open-chain ligands and macrocycles
Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer's disease.
Ligand design for selective complexation of metal ions in aqueous solution
A fluorescent indicator for measuring cytosolic free magnesium.
Measurement of cytosolic free magnesium ion concentration by 19F NMR.
The design of molecular hosts, guests, and their complexes
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Entropy Effects in Chelation Reactions.
Stability constants of Mg2+ and Cd2+ complexes of adenine nucleotides and thionucleotides and rate constants for formation and dissociation of MgATP and MgADP.
The Chelate Effect Redefined.
A non-disruptive technique for loading calcium buffers and indicators into cells
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.
Fluoroimmunoassay: present status and key problems.
Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides
Hard and soft acids and bases, HSAB, part 1: Fundamental principles
HARD AND SOFT ACIDS AND BASES
The Complexes of Magnesium Ion with Pyrophosphate and Triphosphate Ions
Magnesium in man: implications for health and disease.
Calcium Signaling
Actions of ultraviolet light on cellular structures.
The Stable Isotope Use in the Exploration of Bioavailability and Metabolism of Magnesium
A new approach to the synthesis of APTRA indicators.
A model system using modulation of lanthanide luminescence to signal Zn2+ in competitive aqueous media
Synthesis and complex stability of parent and C-functionalised derivatives of 1,4,7-triazacyclononane-1,4,7-tris[methylene(methylphosphinic acid)]: an effective new complexing agent
Serum magnesium levels in the United States, 1971-1974.
Magnesium Metabolism: A Review
Die bindung von adenosindiphosphat, von anorganischem phosphat und von erdalkalien an die strukturproteine des muskels